KUALA LUMPUR, Malaysia — Malaysian Prime Minister Najib Razak says a new analysis of satellite data indicates the missing Malaysia Airlines plane plunged into a remote corner of the Indian Ocean.

The news is a major breakthrough in the unprecedented two-week struggle to find out what happened to Flight 370, which disappeared shortly after takeoff from Kuala Lumpur to Beijing with 239 passengers and crew aboard on March 8.

Dressed in a black suit, Najib announced the news "with deep sadness and regret" in a brief news conference late Monday night.

He said Malaysia Airlines has informed the families of passengers of the plane's fate.

Najib said the information was based on an unprecedented analysis of satellite data from Inmarsat.