ISIS must be fought in the air, on the ground and in cyberspace, Democratic front-runner Hillary Clinton said Tuesday morning, as it is a "barbaric enemy" that has money and controls territory, and Russia should be included in the fight.

"We need to get over the false choice between either going after [Syrian President Bashar al-] Assad," the former Secretary of State told "CBS This Morning" host Charlie Rose.

And the Russians have paid a "big price" because of an ISIS-linked bomb that brought down a commuter jet in October minutes after it left the Sharm el-Sheikh, Egypt resort, killing 224 passengers.

"I think you say, look, we need your, not your active help, your acquiescence in what we will do in going after ISIS," said Clinton. "That means will you have to pull back from this area while we go after their leadership and their economic infrastructure. But if you want to be a part of that, we would welcome you. You have a dog in this hunt now, you are worried at what's happening at caucuses. You are worried about ISIS spreading its ideology."

But she does not expect a military defeat of Assad.

That's not going to happen," she said. "It might have been possible a few years ago. It's not going to happen now.  Right now we won't see a military defeat of Assad."

But meanwhile, Clinton said she agrees with President Barack Obama's decision about not putting American combat troops back into Syria or Iraq at this time.

"At this point I cannot conceive of any circumstances where I would agree to do that," she said. "We don't know yet how many special forces might be needed, how many trainers, enablers...but in terms of thousands of combat troops like some on the Republican side are recommending, I think that should be a non-starter. It should be a non-starter both because I don't think it's the smartest way to go after ISIS. I think it gives ISIS a new recruitment tool if we get back into the fight." 

Clinton also advocates a no-fly zone in the region, and insisted Tuesday that Russia will not violate it.

"We will put up a no-fly zone where the Russians are clearly kept informed," she said. "I want them at the table. They don't have to participate in it. I want them to understand there have to be safe areas on the ground."

ISIS is also growing in power in Libya, and Clinton said that there are powers fighting now in Libya that are not identified with or allied with ISIS.

"They need to form even a loose confederation to try to push ISIS literally into the sea before they get a stronghold," said Clinton.

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