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Tags: alzheimer | treatment | compound

Compound Reverses Alzheimer's Symptoms: Study

Monday, 07 January 2013 10:53 AM EST

A new federally funded study has found that a naturally occurring compound, derived from a key enzyme in the brain, may hold promise for reversing the symptoms and memory loss seen in Alzheimer’s disease patients.
Although the National Institutes of Health study involved laboratory mice, researchers said if the compound — known as TFP5 — is found to be as effective in humans as in rodents, it could offer a significant new weapon to combat the brain-wasting disease.
"We hope that clinical trial studies in [Alzheimer’s] patients should yield an extended and a better quality of life as observed in mice upon TFP5 treatment," said Harish C. Pant, a senior researcher involved in the work from the Laboratory of Neurochemistry at the National Institute of Neurological Disorders at Stroke at the National Institutes of Health in Bethesda, MD. "Therefore, we suggest that TFP5 should be an effective therapeutic compound."
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According to the study, published in the Federation of American Societies for Experimental Biology’s FASEB Journal, TFP5 targets plaques and tangles in the brain associated with Alzheimer’s, effectively restoring memory without obvious toxic side effects.
To test the compound’s effectiveness, Pant and colleagues injected it into mice with a disease that is the equivalent of human Alzheimer's. The results showed the treated mice displayed a substantial reduction in symptoms, compared to a similar group of untreated mice that experienced no changes in their symptoms.
Pant noted TFP5 was derived from the regulator of a key brain enzyme, called Cdk5. The over activation of Cdk5 is tied to the formation of plaques and tangles, the major hallmark of Alzheimer's disease.
"The next step is to find out if this molecule can have the same effects in people, and if not, to find out which molecule will," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Now that we know that we can target the basic molecular defects in Alzheimer's disease, we can hope for treatments far better — and more specific — than anything we have today."

© HealthDay

A naturally occurring compound may hold promise for reversing the symptoms of Alzheimer’s.
Monday, 07 January 2013 10:53 AM
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