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Dr. Gary Small, M.D.

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Misplacing your keys, forgetting someone's name at a party, or coming home from the market without the most important item — these are just some of the many common memory slips we all experience from time to time.


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Gary Small, M.D., is Chair of Psychiatry at Hackensack University Medical Center, and Physician in Chief for Behavioral Health Services at Hackensack Meridian Health, New Jersey’s largest, most comprehensive and integrated healthcare network. Dr. Small has often appeared on the TODAY show, Good Morning America, and CNN and is co-author (with his wife Gigi Vorgan) of 10 popular books, including New York Times bestseller, “The Memory Bible,” “The Small Guide to Anxiety,” and “The Small Guide to Alzheimer’s Disease.”

Tags: inflammation | cognitive decline | depression

Depression Heightens Brain Inflammation

Dr. Small By Thursday, 04 June 2020 04:32 PM Current | Bio | Archive

Brain inflammation is associated with both cognitive decline and depression. A study published in The Lancet Psychiatry now links longer duration of untreated major depressive disorder to greater activation of brain microglia — neural cells involved in the brain’s inflammatory response.

Scientists measured the activity of these cells and determined whether there was an association between that activity level and how long patients had been depressed without being treated for their depression.

The research volunteers were not taking antidepressant medications during the course of the study.

Patients who had not received treatment for depression for 10 or more years had significantly greater microglial activation than those with shorter durations of untreated depression.

Other studies have shown that untreated depression in late life increases risk of developing Alzheimer’s dementia.

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Dr-Small
A study published in The Lancet Psychiatry now links longer duration of untreated major depressive disorder to greater activation of brain microglia.
inflammation, cognitive decline, depression
127
2020-32-04
Thursday, 04 June 2020 04:32 PM
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