In a new study, published in the Journal of Health Psychology, patients who gained weight 18 months after taking Orlistat attributed their weight-loss failure either to side effects which have prevented them from sticking to the medication or felt that it simply had not worked.

 

But researchers from the University of Surrey said it's no so simple. They found that participants faced significant barriers to weight loss, including psychological and physical health issues, that also made other techniques for shedding pounds less successful.
 

"Our results have significant implications for GPs and how they should communicate with the patients about this drug," said lead researcher Amelia Hollywood, M.D. "GPs can improve patient support while taking Orlistat. At present, the so called 'side effects' of Orlistat are seen as unpleasant and intrusive. If health professionals can highlight that such 'side effects' are actually the consequences of eating high-fat foods while taking the drug, it could help ensure a change in diets."
 

Orlistat (sold as Xenical) is currently the only prescribed drug for obesity and functions by reducing the amount of fat absorbed from food eaten.
 

The drug causes changes in bowel function because of the unabsorbed fat. Side effects can include fatty/oily stools, spotting, intestinal gas with discharge, a feeling of urgency, increased number of bowel movements, or incontinence. These side effects may get worse if users eat more fat than is recommended.
 

Allergic reactions to the drug, though rare, have also been reported — including rashes, itching, swelling of the face/tongue/throat, dizziness, and trouble breathing.
 

"By alerting patients to these consequences and emphasizing the need for dietary change, patients may be in a better position to make an informed judgment as to whether they wish to be prescribed this medication," said Dr. Hollywood. "GPs may likewise be able to make a more informed decision as to whether the medication should be prescribed."